Synthesis, Analytical Characterization and Anti-Diabetic Activity of Some Heterocycles of Quinazolin-4(3H)one

Aim: Novel quinazolin-4(3H)-one heterocycles were synthesized and assessed for their anti-diabetic activity. Non-enzymatic glycosylation of haemoglobin assay was carried out to identify potential as anti-diabetic. The cyclization quinazolinone-4(3H)-one achieved, whereas carbon-carbon cross coupling reactions using Sonogashira Suzuki-Miyaura reaction conditions characterized with analysis. This synthesis method afforded corresponding 2, 3 6 substituted quinazolin-4(3H)-ones (3a 3m) excellent yields.
 Methods: 2-Amino-6-bromobenzoic acid used a substrate which converted benzamide derivatives (1a-1b) by benzylamine or cyclohexylamine acid-amine reaction, followed oxidation suitable aldehyde in DMSO under microwave condition give bromo (2a-2c), coupled terminal alkyne palladium catalyst well copper co-catalyst obtain desired (3a-3h) boronic (3i-3m). All compounds FTIR, proton NMR, LC-MS analysis evaluated vitro activity non-enzymatic assay.
 Results: Compounds 3m showed good inhibition turn suggest anti-oxidant on metabolism glucose hence lower concentration. It IC50 value 35.91±0.82 µg/mL comparable the standard alpha tocopherol (34.47±0.87µg/mL).
 Conclusion: In-vitro is one important assays judge control diabetes. present RBCs has an affinity bind glucose. greater level blood, more amount glucose-bound (called glycosylated) will be formed. Accordingly, presence concentration glycosylated sure guide blood. Synthesized (3a-3m) blood highest among those can further developed potent